Prostate Cancer Screening
The phi, or Prostate Health Index, is an index based on the measurement of a new serum marker for prostate cancer, known as [-2]proPSA. [-2]proPSA is an isoform of PSA, which is almost exclusively ex- pressed by prostate cancer cells (which is not the case for total PSA). The combination of total PSA and free PSA in the phi calculation gives rise to a considerable improvement in detection specificity of pros- tate cancer, and as such, significantly reduces the need to perform biopsies.
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